The chorioallantoic membrane (CAM) model is an alternative in vivo test system for studying cancer hallmarks, such as angiogenesis, tumor growth, immune escape, metastasis, and drug resistance. It is suitable for tumor cell lines and patient-derived xenografts (PDX), allowing for studying treatment protocols for cancer patients.
The CAM model is a simple, fast, and low-cost tool to study tumor growth, drug response, or angiogenesis in vivo. It is also a promising new model for immune-oncology-based drug discovery.
However, the CAM model also has some disadvantages and limitations. For example, it is not as well-established as mouse models, and the results obtained from CAM models may not always be directly translatable to humans.
Overall, the CAM model is a valuable tool for cancer research, and it is likely to play an increasingly important role in the development of new cancer treatments.
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